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Concentration-dependent effects of flecainide and quinidine on Kv4.2 currents upon pulsing to +50 mV. Dose–response curves for flecainide (a) and quinidine (b) were fitted to the Hill equation to obtain the IC50 values in Kv4.2WT, N-del, V[402,404]I and N-del/V[402,404]I channels. Each point represents the mean ± s.e.m. of three to 10 experiments.
