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Effects of flecainide (10 μM) and quinidine (10 μM) on voltage-dependent V[402,404]I current activation (a and d) and inactivation (b, e). (c, f) Flecainide- and quinidine-induced blockade related to channel inactivation and activation. The curves are Boltzmann fits of control activation and inactivation curves. Results are mean±s.e. of four experiments.
