Table 4.
mRNA expression in the non−infarcted left ventricle (NILV), and right ventricle (RV) of the 2 week post−MI rat, and the effect of irbesartan (IRB)
| NILV | RV | |||
|---|---|---|---|---|
| MI (n=4) | MI+IRB (n=4–7) | MI (n=4–5) | MI + IRB (n=5–9) | |
| prepro−ANP | 12±5* | 25±3** | 9±2* | 2±1*** |
| mRNA | ||||
| prepro−BNP | 10±2* | 17±4** | 6±2* | 1±1*** |
| mRNA | ||||
| Fibronectin | 5±1* | 8±2** | 4±1* | 4±1** |
| mRNA | ||||
mRNA data in the myocardial infarct (MI) group is presented as fold increase±s.e.m. versus sham rat. MI+IRB mRNA data is presented as fold increase±s.e.m. versus IRB−treated sham rats.
Represents P<0.05 versus sham rat;
Represents P<0.05 versus IRB−treated sham rat;
Represents P<0.05 versus untreated MI rat; mRNA expression was normalized to GAPDH mRNA; and (n) denotes number of rats examined.