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. 2003 May 14;139(1):99–108. doi: 10.1038/sj.bjp.0705221

Figure 2.

Figure 2

Effects of SR33805 on cell electrical activity of rat cardiac myocytes. (a) Superimposed APs elicited under current-clamp conditions in control conditions (solid line) and in the presence of 10−8 (dashed line) and 10−7 M (dotted line) SR33805 (upper panel). Pooled data of action potential duration estimated at 50% repolarization (APD50) in control and in the presence of SR33805 (lower panel). *P<0.05, n = 6. (b) Superimposed L-type Ca2+ current traces recordings elicited in a cell perfused with increasing SR33805 concentrations (upper panel). SR33805 induced a concentration-dependent blockade of ICaL as revealed by the dose–response curve (lower panel). The IC50 of the blockade of ICaL by SR33805 is 2.4 × 10−8 M (n=6 cells).