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. 2003 May 29;139(2):408–414. doi: 10.1038/sj.bjp.0705237

Figure 4.

Figure 4

Effects of cPKC down-regulation on PKCα expression and 12- deoxyphorbol 13-isobutyrate-induced relaxation in pregnant myometrium. Myometrial strips from day 21 pregnant rats were pretreated with thymeleatoxin (10−6 M, THX) for 6 h to downregulate cPKC (THX-pretreated in A and B), or with 0.1% DMSO for control experiments (control in A and B). (A) Expression of PKCα in control and THX-pretreated pregnant myometria. (B and C) Inhibitory effects of 12-deoxyphorbol 13-isobutyrate (DPB) on 40 mM K+-induced tension in control and THX-pretreated pregnant myometria (n=6–8). *Denotes significant difference from the results of control (P<0.05).