Figure 2.

Effect of B₂ kinin receptor blockade on kallikrein-like activities in the pancreatic tissue during caerulein (CRL)-induced pancreatitis. Activities of (a) tissue-type kallikrein (t-KK) and (b) plasma-type kallikrein (p-KK) were determined after a 2 h infusion of CRL using the chromogenic substrates S-2266 and S-2302, respectively. CRL (4 nmol kg⁻¹ h⁻¹) was infused i.v. for 120 min; control rats received phosphate-buffered saline instead. The B₂ antagonist icatibant (ICAT; 100 nmol kg⁻¹) was administered s.c. 20 min before the experiment. Significance of difference as indicated by the horizontal bars: ^*P<0.05. Values are given as individual values (a) or means+s.e.mean (b); n=5–11.