Figure 4.

Effects of increasing concentrations of UK-14,304 on tritium outflow evoked by electrical field stimulation of longitudinal muscle preparations of rat ileum preincubated with [³H] noradrenaline. Electrical stimulation during S₁ and S₂ consisted of 480 pulses (20 V cm⁻¹, 0.5 ms) at 8 Hz. Ileal preparations were obtained from rats either in the absence or in the presence of DNBS-induced colitis. Each point represents the mean of five to six experiments±s.e.m. (vertical bars). Significant difference from the respective values obtained in vehicle-treated animals: ^*P<0.05; significant difference from the respective control values: ^aP<0.05.