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. 2003 May 29;139(2):337–350. doi: 10.1038/sj.bjp.0705267

Figure 2.

Figure 2

Contractions produced by McN-A343 in the absence (control) and presence of the muscarinic antagonist AF-DX116 (a), 4-DAMP (b) and darifenacin (c), applied at various concentrations as indicated in the parentheses. McN-A343 was applied at stepwise increasing (three or 3.3-fold) concentrations at points marked by the closed circles. In (c), carbachol (CCh) was applied in the absence and presence of 30 nM darifenacin, at concentrations as indicated. Note the change in the response pattern and weak overcoming of McN-A343 in the presence of 4-DAMP and darifenacin.