Figure 6.

The effects of the muscarinic agonists on myofilament Ca²⁺ sensitivity in α-toxin-permeabilized preparations. (a and b) Tension responses to ascending concentrations of Ca²⁺ (pCa 6.5–5) before and after application of 100 μM McN-A343 (a) or 100 μM pilocarpine (b). (c) pCa–tension curves in the absence (control) and presence of McN-A343, pilocarpine, and carbachol (CCh). Each point indicates mean±s.e.m. of eights measurements for control, the fives for McN-A343, the fours for pilocarpine, and the eights for carbachol. *Significantly different (P<0.05) from the corresponding value for control.