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The effects of tolbutamide (30, 100 μM) on (a) 500 μM diazoxide- and (b) 10 μM pinacidil- induced inward membrane currents at −50 mV in symmetrical 140 mM K+ conditions by use of nystatin-perforated patch configuration. The dashed line indicates zero current. (c) Tolbutamide (30–500 μM) inhibited the 500 μM diazoxide- and the 10 μM pinacidil-induced inward membrane current at −50 mV in a concentration-dependent manner. Each column indicates the mean 4–5 observations with +s.d.
