Figure 2.

Effects of L-NAME and ODQ on the longitudinal muscle relaxation evoked by PAR-1-and PAR-2-activating peptides in rat colon. The relaxation induced by SFLLRN-NH₂ (1–10 μM), TFLLR-NH₂ (1–10 μM) or SLIGRL-NH₂ (10 μM) was significantly reduced by L-NAME (300 μM) or ODQ (10 μM). Data are means ±s.e.m. of at least four experiments. ^*P<0.05, compared to the control value.