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. 2003 Jun 9;139(3):501–512. doi: 10.1038/sj.bjp.0705276

Figure 2.

Figure 2

(a) Inhibition of [125I]PYY-specific binding by GTPγS in Y1 and Y1C membranes (both n=3). The curves fitted to combined triplicate experiments yielded a pIC50 of 7.41±0.25 in the Y1 clone. (b) Combined PYY displacements under control conditions or in the presence of 1 μM GTPγS in Y1 and Y1C membranes (n=3–6); pIC50 values are quoted in Table 1. (c) Total [125]PYY-specific binding in the absence (100%; n=5–7) or presence of 1 μM GTPγS (n=3). ***P<0.001 for comparisons between Y1 or HAY1 membranes and respective Cys mutant clones.