Table 1.
Anticonvulsant activity of the valproyltaurinamides in the Frings mice
| Compound | ED50 (mg kg−1) (95% CI) | Time of test (h)a |
|---|---|---|
| VTA | >300 | 0.25–4 |
| VTD | 52 (43–62) | 2 |
| I-VTD | 126 (96–174) | 0.5 |
| DM-VTD | 134 (104–168) | 0.5 |
| VPAb | 155 (110–216) | 0.25 |
| VGDc | 52 (39–64) | 0.5 |
Also, the time of peak anticonvulsant effect.
Data from White et al. (2002).
Data from Isoherranen et al. (2001).