Table 5.
Pharmacokinetic parameters of valproyltaurinamide and N-methyl-valproyltaurinamide as metabolites of the investigated N-alkyl-valproyltaurinamides
| PK parameter | VTD from DM-VTD | M-VTD from DM-VTD | VTD from I-VTD |
|---|---|---|---|
| t1/2 metabolite (h) | 3.6 | 0.83 | 1.43 |
| MRTmetabolite (h) | 6.1 | 1.83 | 2.90 |
| AUCplasma (mg l−1 h) | 191 | 188 | 386 |
| AUCbrain (mg kg−1 h) | 46.7 | 103 | 115 |
| MRTbrain (h) | 2.9 | 1.45 | 3.4 |
| AUCbrain/AUCplasma | 0.24 | 0.55 | 0.30 |
| CLr (ml h−1) | 1.5 | 0.69 | |
| fem | 3.9 | 1.7 |
t1/2 metabolite–half-life of the metabolite; MRT–mean residence time; AUC–area under concentration curve; CLr–renal clearance; fem–fraction of the dose excreted in urine as the specific metabolite.