Table 1.
Pharmacokinetic indices of verapamil in control and INF-induced inflamed rats (n=8/group)
| Parameter | Control | Inflamed |
|---|---|---|
| Tmax (min) | ||
| S | 36.4±8.6 | 118.6±25.1*** |
| R | 28.1±7.1 | 69.4±12.3* |
| Cmax (ng ml−1) | ||
| S | 42.4±9.4 | 68.9±15.4 |
| R | 16.1±8.7 | 19.0±8.5 |
| λz (h−1) | ||
| S | 0.46±0.19 | 0.37±0.48 |
| R | 0.57±0.13 | 0.18±0.04* |
| AUC0→8 (μg min−1 ml−1) | ||
| S | 49.6±4.7 | 163.3±33.5** |
| R | 9.7±2.4 | 69.7±19.6** |
| AUC0→∞ (μg min−1 ml−1) | ||
| S | 53.4±6.7 | 178.4±48.2** |
| R | 11.2±2.8 | 74.4±26.6* |
| CL/F (l min−1 kg−1) | ||
| S | 0.22±0.03 | 0.075±0.01* |
| R | 1.5±0.5 | 0.27±0.05* |
| fu | ||
| S | 0.067±0.011 | 0.077±0.0057 |
| R | 0.178±0.017 | 0.184±0.0096 |
*
Significantly different from control. P<0.05
**
P<0.01
***
P<0.001.