Table 2.
Pharmacokinetic parameters of norverapamil in control and IFN-induced inflamed rats (n=8/group)
Parameter | Control | INα2a |
---|---|---|
AUC0→8 (μg min−1 ml−1) | ||
S | 62.0±12.4 | 108.9±15.7* |
R | 14.2±3.5 | 36.0±8.5* |
Norverapamil : verapamil AUC ratio | ||
S | 1.6±0.3 | 0.6±0.2* |
R | 2.5±0.9 | 1.3±0.4 |
λz (h−1) | ||
S | 0.21±0.06 | 0.18±0.1 |
R | 0.20±0.1 | 0.31±0.1 |
Different from control, P<0.05.