Table 2.
Mean pulmonary arterial pressure (PAP) and systemic arterial pressure (SAP) before and after NOS inhibitor injection
| Blood pressure (mmHg) | Control rats | 4-week hypoxia rats |
|---|---|---|
| (1) Nonselective NOS inhibition (NNI) | ||
| PAP (baseline) | 18.0±0.5 | 21.1±1.0* |
| PAP with NNI | 18.6±0.6 | 24.3±1.1*,** |
| PAP with NNI+L-arginine | 17.9±0.6 | 23.3±1.2* |
| SAP (baseline) | 93±6 | 101±7 |
| SAP with NNI | 123±7** | 135±9** |
| SAP with NNI+L-arginine | 98±7 | 108±9 |
| (2) iNOS selective inhibition (ISI) | ||
| PAP (baseline) | 17.2±0.6 | 22.1±1.1* |
| PAP with ISI | 17.4±0.7 | 22.9±1.1* |
| PAP with ISI+L-arginine | 17.1±0.7 | 22.2±1.1* |
| SAP (baseline) | 96±6 | 105±7 |
| SAP with ISI | 98±6 | 113±8 |
| SAP with ISI+L-arginine | 94±7 | 107±8 |
| (3) nNOS selective inhibition (NSI) | ||
| PAP (baseline) | 18.0±0.5 | 22.4±1.0* |
| PAP with NSI | 18.2±0.5 | 22.6±1.0* |
| SAP (baseline) | 94±6 | 102±7 |
| SAP with NSI | 96±6 | 105±7 |
Values are mean+s.e.m. The mean value in classes 1 and 2 was obtained by pooling all the data in response to two different nonselective NOS inhibitors and two iNOS-selective inhibitors, respectively.
*
P<0.05 vs control rats.
**
P<0.05 vs baseline.