Figure 3.

Effects of the coinjection of the selective kinin B₁ receptor antagonists des-Arg⁹-[Leu⁸]-BK (panel a, 100 nmol paw⁻¹) and R715 (panel b, 60 nmol paw⁻¹) on des-Arg⁹-BK-induced paw oedema (100 nmol paw⁻¹) in animals pretreated with PAF (10 nmol paw⁻¹). Effects of the selective PAF receptor antagonist WEB2086 (panel c, 15 μg paw⁻¹) or of PAF receptor desensitisation (panel d) on des- Arg⁹-BK-induced paw oedema (100 nmol paw⁻¹) in animals pretreated with PAF (10 nmol paw⁻¹). Each point represents the mean±s.e.m. of four to six animals. In some cases, error bars are hidden within the symbols. Significantly different from control values ^*P<0.05, ^**P<0.01.