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Effects of metyrapone (a), myxothiazol (b), troleandomycin (c), and allopurinol (d) on NO release from GTN in rat liver homogenate. Experimental conditions were as indicated in Figure 2. All samples contained enzyme substrates at the following concentrations: 2.5 mM GSH, 0.5 mM NADPH, and 0.5 mM NADH. The inhibitors were solved in DMSO, control samples contained the same amount of DMSO but without inhibitors. *P<0.004; **P<0.02; ***P<0.002; n=5.
