Figure 6.

Effects of SOC and other nonselective cation-channel inhibitors on cerebral arteriolar SOCs. Arterioles were in standard (1.5 mM Ca²⁺) or Ca²⁺-free bath solution (0.4 mM EGTA). All solutions contained 10 μM D600. (a) No effect of 10 μM SKF 96365 in a zero Ca²⁺/CPA-treated arteriole, but La³⁺ did reduce [Ca²⁺]_i. (b) In a TG-pretreated arteriole, 10 μM LOE 908 had no effect although Gd³⁺ reduced [Ca²⁺]_i. (c) In an arteriole treated with zero Ca²⁺/CPA, LOE 908 had no effect on [Ca²⁺]_i. (d–h) Effects of 10 μM ruthenium red (d), 100 μM capsaicin (e), 100 μM sulindac (f), 0.5 mM streptomycin (g) and 1:10,000 G. spatulata venom (h) on [Ca²⁺]_i in TG-pretreated arterioles. Only capsaicin (e) had any effect on [Ca²⁺]_i. For agents having no effect, SOC activation was confirmed by Gd³⁺-induced reduction of [Ca²⁺]_i.