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. 2003 Jul 2;139(5):998–1004. doi: 10.1038/sj.bjp.0705328

Figure 2.

Figure 2

Rate metre recordings demonstrating the effect of DOI on 5-HT cell firing either (a) alone or in rats pretreated with (b) the 5-HT2 receptor antagonist ritanserin (1 mg kg−1 i.v.), (c) the 5-HT2A receptor antagonist MDL 100,907 (0.2 mg kg−1 i.v.) or (d) the 5-HT2B/C receptor antagonist SB 206553 (0.5 mg kg−1 i.v.). Antagonists were administered 5 min prior to DOI, which was given in increasing doses at 2 min intervals. Note also the characteristic inhibitory response of the 5-HT neurones to the 5-HT1A receptor agonist 8-OH-DPAT (10 μg kg−1 i.v.).