Figure 6.

Effects of TAK-475 and atorvastatin on plasma lipid levels and transaminase activities in male cynomolgus monkeys. Drugs were administered orally once a day at low doses (30 mg kg⁻¹ for TAK-475 and 10 mg kg⁻¹ for atorvastatin) for 7 days and at high doses (100 mg kg⁻¹ for TAK-475 and 30 mg kg⁻¹ for atorvastatin) for the next 7 days. Initial values of plasma total cholesterol were 137±9, 136±12 and 137±18 mg dl⁻¹ and of plasma triglyceride were 29±3, 38±4 and 39±7 mg dl⁻¹ for the control groups, TAK-475- and atorvastatin-treated groups, respectively. Initial values of AST activity were 23±1, 26±2 and 26±1 IU l⁻¹ and of ALT activity were 49±6, 46±5 and 42±11 IU l⁻¹ for the control group, TAK-475- and atorvastatin-treated groups, respectively. Data are represented as mean±s.e.m. percentage changes from initial values (n=5). ^*P<0.05 and ^**P <0.01 vs control by Dunnett's test.