Table 1.

Lipid-lowering effects of TAK-475 in beagle dogs

Treatment	Non-HDL-C % change	TG % change	HDL-C % change
Control	−6±11	−14±13	−7±2
TAK-475 (30 mg kg−1)	−40±4*	−33±6	−5±2

TAK-475 (30 mg kg⁻¹) or vehicle were administered orally once a day to male beagle dogs for 14 days. The initial values of non-HDL cholesterol (Non-HDL-C) were 24±3 and 27±5 mg dl⁻¹, of triglyceride (TG) were 23±2 and 22±3 mg dl⁻¹ and of HDL cholesterol (HDL-C) were 110±10 and 110±9 mg dl⁻¹ for the control and TAK-475-treated groups, respectively. Data are represented as mean±s.e.m. changes in levels compared with initial values (n=4).

^*P<0.05 vs control values by Student's t-test.