Table 1.
Cardiovascular variables for groups 1 (n=8) and 2 (n=9), before and after 90 min infusion with vehicle (day 1), SMTC (Group 1, day 3) or L-NAME (Group 2; day 3)
| Group 1 | Group 2 | Group 1 | Group 2 | |||||
|---|---|---|---|---|---|---|---|---|
| Day 1 Vehicle | Day 1 Vehicle | Day 3 SMTC | Day 3 L-NAME | |||||
| 0 min | 90 min | 0 min | 90 min | 0 min | 90 min | 0 min | 90 min | |
| Heart rate (beats min−1) | 338±9 | 326±8 | 346±15 | 352±15 | 321±9 | 325±15 | 336±13 | 292±12* |
| Blood pressure (mmHg) | 104±4 | 102±3 | 102±4 | 104±5 | 100±3 | 110±4* | 100±2 | 132±4*# |
| Renal Doppler shift (kHz) | 10±0.7 | 9.9±0.7 | 8.7±0.7 | 9.1±0.6 | 10±0.9 | 9.8±1.0 | 8.2±1.1 | 8.1±1.2# |
| Renal VC (units) | 98±5 | 97±6 | 85±6 | 88±5 | 100±7 | 88±7* | 82±10 | 63±9*# |
| Mesenteric Doppler shift (kHz) | 10±0.7 | 10±0.7 | 10±0.9 | 10±0.9 | 9.5±0.8 | 8.6±0.6* | 9.8±0.9 | 7.3±0.8*# |
| MesentericVC (units) | 106±8 | 100±8 | 107±11 | 100±13 | 96±10 | 80±8* | 99±10 | 55±7*# |
| Hindquarters Doppler shift (kHz) | 4.9±0.8 | 4.2±0.2 | 4.4±0.3 | 4.2±0.3 | 3.9±0.2 | 3.6±0.2 | 3.9±0.4 | 3.0±0.3*# |
| Hindquarters VC (units) | 47±7 | 42±3 | 44±3 | 41±3 | 40±3 | 34±3* | 40±3 | 23±3*# |
Units for vascular conductance (VC) are (kHz mmHg−1)103.
*
P<0.05 vs baseline (Friedman's test)
#
P<0.05 vs Group 1 (SMTC) (Mann–Whitney test).
Values are mean±s.e.m.