Figure 5.

Effects of antidepressants, nAChR ligands, and their combination on locomotor activity of mice. Data are presented as the mean+s.e.m. AUC. Mice were injected with the antidepressant 30 min, and with nicotine 15 min, before the test, respectively; the measurements continued for the next 40 min (a), or with nAChR antagonist 40 min, and with the antidepressant 30 min before the test, respectively; the measurements continued for the next 80 min (b). Plus and minus signs indicate the presence or absence of a given treatment, respectively. The numbers on abscissa represent the doses in mg kg⁻¹. One-way ANOVAs showed no overall effects of treatments.