Figure 1.
Time-course analysis of lung hydroxyproline content in amiodarone-treated rats (a) and the protective effects of curcumin on amiodarone-induced increase in lung hydroxyproline content (b). Rats were killed at several time points after i.t. administration of amiodarone and lung hydroxyproline levels were measured as described under the Methods section. All data are expressed as mean±s.d. (n=6 rats group−1 time point−1). Since there was no statistical difference between water- and curcumin-treated control groups, we show the values of water-treated groups as controls. *Significantly (P<0.01) higher than control groups (dotted line); †significantly (P<0.01) lower than CR(0)+AMD group; hydroxyproline values in CR(50)+AMD and CR(100)+AMD groups are not statistically different from CR(0)+AMD group; CR: curcumin; AMD: amiodarone; d: day; w: week.