Figure 3.

Effects of curcumin on amiodarone-induced increases in lung inflammation as reflected by influx of inflammatory cells into airspaces. BALF was performed at several time points after i.t. administration of amiodarone, and changes in total cells (a) alveolar macrophages (b) neutrophils (c) and eosinophils (d) were measured as described under the Methods section. Since there was no significant difference in total and differential cell counts recovered by BALF at latter time points between control and amiodarone groups, we present the data for 3 and 5 days postamiodarone administration. All data are expressed as mean±s.d. (n=6 rats group⁻¹ time point⁻¹). ^*Significantly (P<0.01) higher than control groups; ^†significantly (P<0.01) lower than the amiodarone group. CON: water-treated controls; CR: curcumin; AMD: amiodarone; d: day; w: week.