Table 1.

time-course anlaysis of various biochemical and cellular constituents in water- and curcumin-treated control groups

Parameters	Day 3	Day 5	Week 1	Week 3	Week 5
Hydroxyproline
Control	18.65±2.72	18.27±2.51	18.81±13.13	19.99±2.82	21.09±2.39
Curcumin	17.97±1.98	17.36±2.53	18.40±3.26	18.72±3.51	19.03±2.84
Total protein
Control	122.48±0.9	118.04±13.9	128.6±9.10	134.13±9.91	117.3±20.1
Curcumin	125.47±12.1	119.79±15.3	130.82±11.3	121.77±14.6	96.69±12.5
LDH
Control	41.39±3.98	44.29±3.82	40.20±4.50	41.55±3.04	38.78±4.96
Curcumin	43.32±3.53	45.69±2.71	39.63±3.94	41.92±5.27	36.14±5.60
Total cells (× 106)
Control	6.15±0.63	5.77±0.40	6.41±0.75	6.06±0.78	6.25±0.73
Curcumin	6.08±0.70	5.96±0.26	5.88±0.56	5.70±0.48	5.36±0.62
AM (× 106)
Control	6.04±0.62	5.65±0.40	6.11±0.76	5.96±0.79	6.13±0.74
Curcumin	5.90±0.66	5.80±0.30	5.77±0.55	5.58±0.48	5.32±0.65
Neutrophils (× 105)
Control	0.047±0.007	0.042±0.008	0.051±0.012	0.049±0.011	0.043±0.026
Curcumin	0.046±0.01	0.045±0.008	0.044±0.015	0.040±0.007	0.035±0.015
Eosinophils (× 105)
Control	0.021±0.004	0.022±0.006	0.019±0.006	0.023±0.007	0.024±0.009
Curcumin	0.023±0.013	0.021±0.008	0.024±0.008	0.020±0.004	0.019±0.008
MPO
Control	6.78±1.36	6.90±0.74	6.48±0.96	7.31±1.39	6.30±1.31
Curcumin	6.15±0.92	5.60±0.47	5.76±0.58	6.39±1.02	5.27±0.81
TNF-α
Control	4.46±0.97	5.05±1.22	4.84±1.31	4.63±0.84	4.38±0.92
Curcumin	4.04±1.22	3.63±0.61	4.39±0.72	4.52±0.79	3.82±0.68
Superoxide anion
Control	9.30±1.99	8.86±1.49	9.44±1.67	10.4±2.63	10.9±3.25
Curcumin	6.79±0.95	7.13±0.79	6.95±1.15	7.25±0.74	7.02±1.75

Values are expressed as mean±s.d. (n=6 rats group⁻¹ time point⁻¹). No statistical difference was observed in any of the above parameters between water- and curcumin-treated control groups over the 5-week study period. AM: alveolar macrophages; LDH: lactate dehydrogenase; MPO: myeloperoxidase; TNF-α: tumor necrosis factor-α.