Figure 6.

Effect of 60 μM bupivacaine on the response to current injection of a dorsal root ganglion neurone. The resting potential of this neurone was −64 mV. Membrane stimulation in current-clamp mode by low-amplitude current pulses of +30, −10, −20 and −30 pA in the absence and presence of 60 μM bupivacaine. The representative traces are shown superimposed on the right (control, continuous line; bupivacaine, dotted line; n=6). Membrane potential was kept at −64 mV in both solutions. Note that bupivacaine abolishes the rectification component and increases the voltage displacement caused by hyperpolarizing current flow.