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Effect of 100 μM CHF3381 on whole-cell Na+ currents in neuroblastoma cells. Cell cultures were prepared and whole-cell patch recordings were made as described in the Methods section. CHF3381 was tested holding cells to −90 (a) or to −60 (b) mV for 90 ms and then depolarising to 0 mV. Left trace (control): representative control Na+ current. Middle trace (CHF3381): Na+ current in the presence of CHF3381. Right trace (wash): Na+ current after wash-out of CHF3381.
