Table 2.
Effect of KB on the resting and action potentials of mouse ventricular myocytes
| Ruptured patch (n=8) | Perforated patch (n=7) | |||
|---|---|---|---|---|
| Control | KB | Control | KB | |
| Vrest (mV) | −71±1.2 | −72±1.0 | −74±0.6 | −76±1.5 |
| APA (mV) | 100±7.1 | 98±5.7 | 116±3.4 | 118±4.2 |
| APD50 (ms) | 6±0.6 | 48±18.2* | 17±3.7 | 74±13.6* |
| APD90 (ms) | 52±13.4 | 143±13.0* | 155±16.5 | 198±10.4* |
Values are given as mean±s.e.m. Same cells used in the absence and presence of 3 μM KB. Recordings made at room temperature, during pacing at 1 Hz. Vrest: resting potential; APA: amplitude of action potential; action potential duration (APD) measured at 50% (APD50) or at 90% (APD90) repolarization;
*
P<0.05; compared to control.