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. 2003 Aug 15;139(8):1516–1522. doi: 10.1038/sj.bjp.0705386

Figure 4.

Figure 4

(a) Effects of PD 98059 on ET-1-induced arachidonic acid release in VSMCs. The cells were incubated for 15 min with various concentrations of PD 98059 and then stimulated with 10 nM ET-1 for 5 min. ERK1/2 activity was determined as described in Methods. Data presented are the mean±s.e.m. of six determinations, each done in triplicate. (b) Effects of PD 98059 on ET-1-induced EGFR PTK transactivation. The cells were incubated for 15 min with or without 30 μM PD 98059 and then stimulated with 10 nM ET-1 for 2 min. EGFR PTK activity was determined as described in Methods. Data presented are the mean±s.e.m. of six determinations, each done in triplicate.