Figure 4.

The effects of infusion of d-amphetamine (cumulative: 10 and 100 μM, ‘10+100'; or 100 μM alone ‘100') on noradrenaline (‘NA') efflux in the frontal cortex (FCx) or hypothalamus (Hyp) of freely moving rats. (a) Shows the results from animals that were given d-amphetamine, only. (b) All animals were given a systemic injection of the α₂-adrenoceptor antagonist, atipamezole (‘Ati', 1 mg kg⁻¹; i.p.), 2 h before infusion of d-amphetamine. The duration of infusions of d-amphetamine are indicated by the solid bars. Noradrenaline efflux is expressed as fmol 20 min⁻¹ and points show mean±s.e.m. N=9 – 11 in each group. For results of statistical analysis, see text.