Figure 6.

Quantitation of β-cell proliferation and mass (volume fraction) in ZDF experiments. Study 1a: after 6 weeks treatment, β-cell volume fraction was increased in both the low- and high-dose liraglutide groups, though only statistically significant for the low-dose group (P<0.05) There was a weak trend towards increased β-cell proliferation as estimated by the BrdU indices. Study 1b: β-cell volume fraction in liraglutide-treated and pair-fed groups were higher than in the lean control group, but not significantly higher than in the vehicle-treated ZDF rats. There was no difference between the β-cell proliferation rates of the three groups of ZDF rats. Study 1c: β-cell volume fraction was significantly lower in the animals treated with liraglutide (P<0.002), and this relative decrease occurred concomitantly with a markedly reduced β-cell proliferation (P<0.006).