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. 2003 Jul 29;140(1):123–132. doi: 10.1038/sj.bjp.0705397

Figure 8.

Figure 8

OGTTs in experiments performed in 60% pancreatectomized rats. After an overnight, fast glucose (2 g kg−1) was administered by gavage at time 0 to overnight fasted animals and BG was measured basally and after the glucose challenge. Top: study 2a. After dosing vehicle or 100 μg kg−1 liraglutide b.i.d. for 4 days, a nonsignificant trend towards improved glucose tolerance was observed in the treated animals. Bottom: study 2b. After dosing vehicle or 150 μg kg−1 liraglutide b.i.d. for 4 days, significantly lower AUC for BG was observed in both the vehicle and pair-fed groups. Furthermore, pair feeding itself resulted in slightly, but significantly, reduced delta AUC during the OGTT.