Table 1.
Baseline values of ‘initial' reflex-evoked changes in bladder and urethral pressures caused by intravesical infusion of saline for each experimental group in urethane anaesthetized female rats for the cystometric study
| n | Bladder thresholds | Micturition-evoked bladder contraction | ||||
|---|---|---|---|---|---|---|
| Experimental group | Pressure (mmHg) | Volume (ml) | Amplitude (mmHg) | Duration (s) | Residual volume (%) | |
| Saline i.c.v. | ||||||
| 5 μl | 5 | 7.1±0.6 | 0.42±0.03 | 20.6±1.7 | 19.8±2.2 | 34±5 |
| SB-269970 i.c.v. | ||||||
| 3 μg kg−1 | 6 | 6.9±0.8 | 0.54±0.05 | 13.7±1.2 | 19.9±1.5 | 40±5 |
| 10 μg kg−1 | 5 | 6.7±0.7 | 0.65±0.04 | 19.6±1.0 | 24.5±2.0 | 43±4 |
| 30 μg kg−1 | 6 | 7.2±0.6 | 0.41±0.03 | 19.4±1.7 | 25.6±2.0 | 44±4 |
| 100 μg kg−1 | 5 | 5.4±0.6 | 0.41±0.03 | 17.3±1.3 | 17.9±1.0 | 34±5 |
| 300 μg kg−1 | 5 | 5.6±0.5 | 0.53±0.06 | 16.2±0.6 | 18.4±1.7 | 41±7 |
| 25% PEG/DMSO i.c.v. | ||||||
| 5 μl | 5 | 8.7±0.6 | 0.6±0.1 | 11.3±0.8 | 22±1.2 | 33±3 |
| SB-656104 i.c.v. | ||||||
| 30 μg kg−1 | 5 | 4.8±0.7 | 0.6±0.1 | 12.0±0.03 | 24.3±2.3 | 20±3 |
| Saline i.t. | ||||||
| 5 μl | 4 | 8.7±1.0 | 0.68±0.10 | 11.4±1.1 | 19.4±1.0 | 40±6 |
| SB-269970 i.t. | ||||||
| 30 μg kg−1 | 4 | 4.9±1.0 | 0.40±0.04 | 18.0±1.0 | 17.1±1.2 | 76±22 |
| WAY-100635 i.t. | ||||||
| 10 μg kg−1 | 4* | 4.4±0.9 | 0.43±0.04 | 18.1±2.5 | 19.3±2 | 63±6 |
| Saline i.v. | 4 | 4.2±0.7 | 0.7±0.12 | 13.9±0.7 | 29.1±5.7 | 50±8 |
| SB-269970 i.v. | ||||||
| 10 μg kg−1 | 5 | 6.5±1.1 | 0.76±0.09 | 15.2±0.6 | 22.5±1.1 | 46±5 |
*
Same animals as for i.t. SB-269970.