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. 2003 Jul 29;140(1):71–80. doi: 10.1038/sj.bjp.0705402

Figure 2.

Figure 2

Neutropenia induced by gut ischaemia–reperfusion. Gut I/R caused significant reduction in circulating PMN levels compared with sham-operated animals (a–c). Pretreatment of rats with (a) sPLA2 inhibitor (5 mg kg−1 i.v. or 10 mg kg−1 p.o.) significantly inhibited I/R-induced neutropenia; (b) celebrex (10 mg kg−1 i.v.) or flunixin (1 mg kg−1 i.v.) had negligible effect for up to 2 h postischaemic phase; (c) zafirlukast (1 mg kg−1 i.v.) resulted in significant improvement in I/R-induced neutropenia. Both flunixin and zafirlukast caused neutrophilia at 2–3 h postischaemic phase. Data are shown as means±s.e.m. (n=6–10 in each group). *, P<0.05 vs I/R animals between groups. Bar shows 30 min period of ischaemia.