Figure 4.

ASA induction by gut ischaemia–reperfusion. Gut I/R resulted in a significant increase in plasma AST levels compared to sham-operated animals. Pretreatment with the sPLA₂ inhibitor (5 mg kg⁻¹ i.v., 10 mg kg⁻¹ p.o.) or zafirlukast (1 mg kg⁻¹ i.v.) or celebrex (10 mg kg⁻¹ i.v.), but not flunixin (1 mg kg⁻¹ i.v.), significantly reduced gut I/R-induced AST levels compared to I/R animals. Drug-treated groups also showed significant increase against sham-operated animals level of AST. Data are shown as means±s.e.m. (n=6–10 in each group). *, P<0.05 vs sham-operated animals. +, P<0.05 vs I/R animals.