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Effect of MK-886 (10 μM) on concentration–response curves for noradrenaline in aortic rings with (E+) or without (E−) endothelium from Methocel, L-NAME, L-NAME-MK-886 and MK-886 rats. Results are expressed as a percentage of the contraction elicited by 90 mM KCl and are presented as means±s.e.m. of experiments performed on n aortic rings as indicated in Table 2. *P<0.05 vs respective vehicle.
