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(a) Concentration–response curves for LTD4 in aortic rings with endothelium from Methocel and L-NAME rats. (b) Effect of MK571 (1 μM) on LTD4-evoked vascular effects in aortic rings with endothelium from L-NAME rats. Results are expressed as a percentage of relaxation/phenylephrine-induced tone and are presented as means±s.e.m. of experiments performed on four aortic rings from four Methocel and four L-NAME rats. *P<0.001 vs Methocel rats, **P<0.05 vs vehicle.
