Table 3.
Release of CysLTs in response to noradrenaline (0.3 μM) or vehicle (control values) in aortic rings from Methocel, L-NAME, L-NAME-MK-886 and MK-886-treated rats
| Methocel | L-NAME | L-NAME-MK-886 | MK-886 | |
|---|---|---|---|---|
| With endothelium | ||||
| Noradrenaline | 120.0±22.1 | 199.4±26.8* | 102.1±11.3 | 121.6±13.7 |
| n | 6 | 6 | 6 | 6 |
| Without endothelium | ||||
| Noradrenaline | 98.49±31.5 | 116.8±15.7 | 110.1±25.8 | 93.9±17.0 |
| n | 6 | 6 | 6 | 6 |
Results are expressed as per cent over the respective control values and are presented as mean±s.e.m. In rings with endothelium, the control values were: (pg mg−1dry weight tissue) 32.6±3.9 (n=7), 24.7±1.8 (n=11), 18.8±5.1 (n=6) and 20.9±1.5 (n=6) for Methocel-, L-NAME-, L-NAME-MK-886- and MK-886-treated rats, respectively. In rings without endothelium, the control values were: 37.7±5.4 (n=6), 31.0±4.5 (n=7), 19.4±2.4 (n=6) and 35.8±5.8 (n=6) for Methocel-, L-NAME-, L-NAME-MK-886- and MK-886-treated rats, respectively. n refers to the number of aortic rings.
*P<0.05 vs respective control values.