Table 2.
Calcium-imaging experiments characterizing the pharmacology of chimeric and wild-type P2X receptors
| ATP | α,β-meATP | ATPγS | BzATP | 2-meS-ATP | ADP | |
|---|---|---|---|---|---|---|
| EC50 (μM) | EC50 (μM) | EC50 (μM) | EC50 (μM) | EC50 (μM) | EC50 (μM) | |
| P2X3 | 0.40±0.03 | 0.78±0.08 | 0.55±0.04 | 0.04±0.03 | 0.18±0.04 | 15.00±1.27 |
| P2X2–3 | 0.27±0.02 | 1.21±0.11 | 4.35±0.48 | 0.01±0.004 | 0.04±0.004 | 15.27±2.54 |
| P2X3–2 | 0.24±0.02 | 18.84±2.49 | 0.36±0.06 | 0.31±0.09 | 0.29±0.05 | 32.19±0.60 |
| P2X2 | 1.07±0.13 | >30 | 0.88±0.04 | 1.05±0.32 | 0.56±0.03 | >100 |
Each value represents the mean EC50±s.e.m. values (μM) calculated from 2 to 16 concentration–response curves run in duplicate.