Table 1.
Electrophysiological characterization of chimeric and wild-type P2X receptor pharmacology
| ATP | α,β-meATP | |||
|---|---|---|---|---|
| EC50 (μM) | nH | EC50 (μM) | nH | |
| P2X3 | 0.13±0.06 | 1.4±0.22 | 0.62±0.03 | 1.5±0.15 |
| P2X2–3 | 0.33±0.03 | 1.8±0.62 | 1.97±0.06 | 1.8±0.31 |
| P2X3–2 | 0.97±0.01 | 1.3±0.01 | 23.4±0.02 | 1.8±0.07 |
| P2X2 | 7.36±0.03 | 1.5±0.11 | >300 | >2 |
Each value represents the best fit of a logistic equation to the averaged data from concentration–response curves from three to six cells. Values are mean EC50±s.e.m. (standard error of the mean); nH=Hill slope.