Figure 2.

Effect of oral SR 144528 on ulcers, TNF-α production and MPO activity induced by indomethacin in the rat ileum. SR 144528 (0.3–30 mg kg⁻¹) was given 6 h after indomethacin (20 mg kg⁻¹ s.c.) and rats were killed 24 h later. Results are expressed as mean %±s.e.m. of indomethacin effect (100%) from at least 12 animals per dose. Basal values were: number of ulcers 0, MPO 0.21±0.06 μU mg⁻¹ protein, TNF-α 25±4 pg mg⁻¹ protein, in the vehicle-treated rats; number of ulcers 111±4, MPO 0.65±0.05 μU mg⁻¹ protein, TNF-α 142±13 pg mg⁻¹ protein, in indomethacin-treated rats. **P<0.01 vs control vehicle (Duncans's test).