Table 1.

Inhibition (ID₅₀ mg kg⁻¹, p.o.) of IND-induced ulcers, TNF-α production and myeloperoxidase (MPO) activity in the rat small intestine by SR 141716 and SR 144528

	Ulcers	TNF-α	MPO
SR 141716	3.32 (2.84–3.95)	0.43 (0.17–0.62)	∼30a
SR 144528	∼7b;	>30	>30

In parentheses, 95% confidence limits.

^aMaximal inhibition 50%.

^bMaximal inhibition 60%.