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. 2003 Aug 4;140(2):247–254. doi: 10.1038/sj.bjp.0705433

Figure 1.

Figure 1

Characterization of the depressor effects of the PAR-2 activators SLIGRL-NH2 (left) and trypsin (right) in rats. (a, b) SLIGRL-NH2 and trypsin were administered i.v. to rats. n=10 (vehicle) or 4–6 (others). The basal MAP (mmHg) was 96.9±5.0 (a) and 115.8±2.7 (b). (c, d) L-NAME (30 mg kg−1) was administered i.p. 15 min before i.v. SLIGRL-NH2 (300 nmol kg−1) or trypsin (65.6 nmol kg−1). Indomethacin (Indo) (20 mg kg−1) was given s.c. 30 min before SLIGRL-NH2. n=4–6. L-NAME continuously elevated MAP (mmHg) from 106.0±6.6 to 146.3±4.8 (c) and from 103.5±3.2 to 154.8±3.0 (d). (e, f) The same doses of PAR-2 activators as (c, d) were administered i.v. 10 days after capsaicin treatment. Cap (+) and (−), treated with capsaicin and vehicle, respectively, n=4–7. Capsaicin treatment unaffected the basal MAP. *P<0.05, **P<0.01 vs vehicle in (a, b), vehicle+vehicle in (c, d), or Cap (−)+vehicle in (e, f); †P<0.05 vs vehicle+PAR-2 activator in (c, d).