Figure 7.

Inhibition of staurosporine-induced aggregation is time-dependent. U937 cells were incubated in the presence of inhibitors either 1.5 h before, at the same time as, or 1.5 h after staurosporine (100 nM). The inhibitors were used at the following concentrations: GF109203X (80 μM), PD98059 (50 μM) and genistein (100 μM). Aggregation was measured after 4 h. Aggregation is expressed as a % of the aggregation obtained in the absence of inhibitor. Mean±s.e.m. of three experiments, and values that differ significantly (Student's t-test, P<0.05) from 100% are indicated by an asterisk.