Effects of baclofen (a), GHB (b) and muscimol (c) on body temperature in GABAB+/+, GABAB+/− and GABAB−/− mice. Drugs were administered at time 0; n=11 (eight males), 12 (seven males) and 9 (five males) (GABAB+/+, GABAB+/− and GABAB−/− baclofen groups, respectively); n=9 (five males), 11 (three males) and 14 (eight males) (GABAB+/+, GABAB+/− and GABAB−/− GHB groups, respectively); n=8 (six males), 9 (five males) and 6 (four males) (GABAB+/+, GABAB+/− and GABAB−/− muscimol groups, respectively); ***P<0.001, Student's t-test.