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Effect of SOD mimic M40403 on superoxide production from human neutrophils. Spin-trapping measurements were performed using the spin trap DEPMPO, 10 mM, with 0.4 M PMN stimulated with PMA, 200 ng/ml. The spectra shown were recorded 30 min post activation. (a) Control-activated PMNs; (b) in the presence of 2.5 M M40403. EPR spectra were recorded in a flat cell on a Bruker ESP300 spectrometer, using a TM110 cavity with 100 kHz modulation frequency.
