Table 2.

Summary of the anti-inflammatory properties of Mn(II)-based selective superoxide mimetics (e.g. M40403)

Inhibition of the upregulation of adhesion molecules (ICAM-1, P-selectin) and PMNs infiltration at the inflamed site

Attenuation of proinflammatory cytokine release (TNFα, IL-1β, IL-6)

Protection of the inactivation of nitric oxide and preservation of its beneficial effects

Inhibition of lipid peroxidation and cellular protection

Attenuation of DNA damage and subsequent activation of poly-ADP-ribose polymerase

Attenuation of peroxynitrite formation and subsequent peroxynitrite-mediated damage

Protects against superoxide anion-driven deactivation of catecholamines – important immunoregulators

Inhibition of the activation of transcription factors (NFκB)